Liliha was reared in the traditional cultural system of the day. As a young woman, Liliha witnessed Ka‘ahumanu’s successful assault on the ancient kapu system. She was the wife of Kahalaia, but was soon preempted by his uncle, Boki, the governor of O‘ahu. Boki, Liliha, and Kekūanāo‘a were principal members of the entourage that accompanied Liholiho (King Kamehameha II) and Kamāmalu his Queen) on an 1824 diplomatic tour of the United Kingdom, visiting King George IV.
Liholiho and Kamāmalu contracted measles. King George IV encouraged Boki and Liliha “to take good care of the missionaries for they were sent to teach the nation the word of God and to enlighten them”. (Damon) However, they had serious disagreements with the missionaries and Ka‘ahumanu, their strong supporter. Liliha died on August 24, 1839 in Honolulu.